Article 6218

Title of the article

A STUDY OF THE PHARMACOLOGICAL ACTIVITY OF A MONTMORILLONITE-BASED ENTEROSORBENT
ON THE MODEL OF ACUTE TOXIC HEPATITIS 

Authors

Tishin Anton Nikolaevich, Therapeutist, admission department, Orel Regional Clinical Hospital (10 Pobedy boulevard, Orel, Russia), 
antoshatishin@yandex.ru
Pokrovskiy Mikhail Vladimirovich, Doctor of medical sciences, professor, head of sub-department of pharmacology, Belgorod State National Research University (85 Pobedy street, Belgorod, Russia), pokrovskii@bsu.edu.ru

Index UDK

615.246.2

DOI

10.21685/2072-3032-2018-2-6

Abstract

Background. Evaluation of detoxification properties of enterosorbent on the basis of montmorillonite under the laboratory code Crim_04.
Materials and methods. The object of the study is a prototype of an enterosorbent based on montmorillonite under the laboratory code Crim_04. The study was carried out by laboratory rats of the Wistar line. Acute toxic damage to the liver caused intragastric administration of 1 ml of 50 % carbon tetrachloride for 6 days and a single intraperitoneal injection of S. thyphi lipopolysaccharide 20 μg/kg on day 7. Water suspensions of enterosorbents were administered intragastrically from 3 to 6 days.
Results. When using enterosorbent under the Crim_04 cipher on the model of acute toxic liver damage, the activity of aspartate aminotransferase in rat blood plasma was 315,2 ± 4,2 U/L, the activity of alanine aminotransferase was 121,6 ± 3,1U/l, the activity of alkaline phosphatase decreased to 208,4 ± 4,5 U/l, decrease in urea levels to 7,9 ± 1,9 mmol/l, creatinine to 89,5 ± 3,3 μmol/l and total bilirubin up to 6,9 ± 1,4 μmol/l, which was significantly lower than in the control group.
This effect was dose-dependent and confirmed during morphological examination.
Conclusion. The enterosorbent under the Crim_04 cipher has a dose-dependent detoxification effect on the model of acute liver damage.

Key words

enterosorption, enterosorbents, montmorillonite, toxic hepatitis

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Дата создания: 24.10.2018 15:50
Дата обновления: 03.12.2018 15:57